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Wnt Synergist, QS11

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Formula: C36H33N5O2
CAS: 944328-88-5
search Element: synergist qs11
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Identification

Structural Formula
Wnt Synergist, QS11
CAS:
944328-88-5
EINECS:
Molecular Formula:
C36H33N5O2
MDL:
SMILES:
C1CC2=C(C1)C=C(C=C2)OC3=NC4=C(C(=N3)N[C@@H](CC5=CC=CC=C5)CO)N=CN4CC6=CC=C(C=C6)C7=CC=CC=C7
Synonym:
(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol ;


Description

Wnt Synergist, QS11 is a cell-permeable purine compound that binds GTPase activating proteins of ADP-ribosylation factor (ARFGAPs), including AMAP1 (Kd = 364 nM) and ARFGAP1 (Kd = 620 nM) and acts as a broad specificity ARFGAP1 inhibitor. Wnt Synergist, QS11 has also been reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 μM).

Additionally, Wnt Synergist, QS11 has been shown to work synergistically with Wnt-3a to specifically activate the Wnt/β-catenin signaling pathway in vitro. A Super(8X)TOPFlash reporter assay using HEK293 cells revealed increases in basal transcription activity by application of QS11 (2-fold), Wnt-3a (40-fold), and QS11/Wnt-3a (200-fold).


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Properties for Wnt Synergist, QS11

Molecular Weight:
567.68 g·mol−1
Density:
~1.28 g/cm3 (Predicted)
Boiling point:
~852.19° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (100 mM), and ethanol (100 mM).
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Alternative Distributors of [Wnt Synergist, QS11]

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