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Vincristine Sulfate

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Formula: C46H56N4O10 . H2SO4
CAS: 2068-78-2
search Element: vincristine sulfate
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Identification

Structural Formula
Vincristine Sulfate
CAS:
2068-78-2
EINECS:
218-190-0
Molecular Formula:
C46H56N4O10 . H2SO4
MDL:
MFCD00084729
SMILES:
OS(O)(=O)=O.CC[C@]1(O)C[C@H]2C[N@@](C1)CCC1=C(NC3=C1C=CC=C3)[C@@](C2)(C(=O)OC)C1=C(OC)C=C2N(C=O)[C@@H]3[C@]4(CCN5CC=C[C@](CC)([C@@H]45)[C@@H](OC(C)=O)[C@]3(O)C(=O)OC)C2=C1
Synonym:
vincrisul ; nsc67574 ; lilly37231 ; onkovin ; novopharm ; v5 peptide ; kyocristine ; vincristin ; vcr ; oncovin


Description

Vincristine Sulfate, a dimeric Vinca alkaloid, has been shown to bind to Tubulin via a protein self association reaction. This compound acts as a Tubuiln inhibitor by binding to sites at the ends of microtubules, which regulate the inhibition of Tubulin dimer addition to microtubule ends. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis and cell cycle arrest at G2/M. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses. Vincristine Sulfate is an inhibitor of MAO. Vincristine Sulfate is also a substrate of PGP and CYP3A4.


Suppliers

Autech Industry Co.,Limited
AIC10264104
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI262210488
+
H&Z Industry Co.,Ltd
HIC7603040
+
Minakem
M266532
+
Shandong SanYoung Industry Co., Ltd
SSI13305320
+
Chemlyte Solutions
CS6842052
+
Indofine Chemical Co, Inc.
06-1319
Guangzhou Topwork Chemical Co., Ltd.
GTC13685472
+
scienTEST - bioKEMIX GmbH
S-B9503800
+
Finetech Industry Limited
FIL9503800
+
Carbone Scientific Co., Ltd.
CS10643192
+
AK Scientific, Inc.
AS7222166
+
Xingrui Industry Co., Limited
XIL11024408
+
Capot Chemical Co., Ltd.
45500
+
Amadis Chemical Company Limited
ACCL11785890
+
Santa Cruz Biotechnology, Inc.
201434
Dayang Chem (Hangzhou) Co.,Ltd.
DC11784712
+
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Alfa (A Johnson Matthey Company)
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Prices & Availability




Data is processed


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Properties for Vincristine Sulfate

Molecular Weight:
923.04 g·mol−1
Melting point:
300 °C
Boiling point:
273-281 °C
Solubility:
Soluble in water (25 mg/ml), ethanol, and methanol.
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Safety & Transport Information

Risk Codes:
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R61 - May cause harm to the unborn child
R62 - Possible risk of impaired fertility
R63 - Possible risk of harm to the unborn child
R68 - Possible risk of irreversible effects
Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Classes:
6.1(a)
Hazard Symbols:
T
Hazard symbol T
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 2
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Alternative Distributors of [Vincristine Sulfate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Advance Scientific & Chemical, Inc. | Inter-Chemical Ltd. | Rongkang Industry Co.,Ltd - (NSTU Chemicals Hanggzhou Co.,) | Ningbo Zhengrun Chemicals Co., Ltd. Exp. Dept. | Molekula GmbH | Hallochem Pharma Co., Ltd. | 3B Scientific Corporation | Argosi International Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | Lemandou Chemicals Co., Ltd. | Toptechlab Pharmaceutical Co., Ltd. | New Dragon Industrial Co., Ltd | ShangHai Biochempartner Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Hubei Honch Pharmaceutical Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | Hangzhou Pharma & Chem Co. Ltd. | Lanospharma Laboratories Co., Ltd. | Nantong Wanrong International Trading Co., Ltd. | Jinan Great Chemical Co., Ltd. | ZhangJiaGang CAE International Trading Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Taizhou Creating Chemical Co., Ltd. | Pharmfar Co., Ltd. | Aopharm | Watson International Ltd | BOC Sciences | Skyrun Industrial Co., Ltd. | Finetech Industry Limited | Jinan Haohua Industry Co., Ltd. | Norn Pharmtech (Shanghai) Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Clearsynth Canada INC. | Haihang Industry Co., Ltd.

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