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Vatalanib Dihydrochloride

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Formula: C20H15ClN4.2HCl
CAS: 212141-51-0
search Element: dihydrochloride vatalanib
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Identification

Structural Formula
Vatalanib Dihydrochloride
CAS:
212141-51-0
EINECS:
Molecular Formula:
C20H15ClN4.2HCl
MDL:
MFCD08458964
SMILES:
C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
Synonym:


Description

Vandetanib Dihydrochloride inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival. Vatalanib Dihydrochloride also inhibits Flk, c-Kit and PDGFR-β with IC50 of 270 nM, 730 nM and 580 nM, respectively. Furthermore, Vatalanib Dihydrochloride shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs


Suppliers

Ambeed, Inc.
A392716
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Chemlyte Solutions
CS9002700
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Finetech Industry Limited
FIL12505000
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Xingrui Industry Co., Limited
XIL14505800
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Leap Chem Co., Ltd
LC9002700
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Santa Cruz Biotechnology, Inc.
202379
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CAS equal suppliers

Vatalanib
Aea.ltd
A63126
Vatalanib 2HCl
Excenen Pharmatech Co., Ltd.
EX-A334
Vatalanib 2HCl
CSNpharm, Inc.
CSN12454

Prices & Availability




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Properties for Vatalanib Dihydrochloride

Molecular Weight:
419.73 g·mol−1
Melting point:
244-246° C
Solubility:
Soluble in DMSO (30 mg/mL), ethanol (10 mg/mL) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/mL ).
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Safety & Transport Information

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Alternative Distributors of [Vatalanib Dihydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Sanowart Group Co., Ltd. | Yangzhou Siyu Chemical Co., Ltd. | Nebula Chemicals Co, Ltd. | Watson International Ltd | Clearsynth Canada INC. | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Boyle Chemical Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | Langfang Bairui Pharmachem Co., Ltd. | D&P Global Chemical Co., Ltd

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