3,5,4′-Trimethoxystilbene | CAS 22255-22-7

Element: trimethoxystilbene prime

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C-S » Chemicals » trimethoxystilbene-PX79356

Identification

3,5,4′-Trimethoxystilbene

CAS:

22255-22-7

EINECS:

Molecular Formula:

C₁₇H₁₈O₃

MDL:

MFCD02093500

SMILES:

COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC

Synonym:

3,4',5-trimethoxy-trans-stilbene ; (e)-1,3-dimethoxy-5-(4-methoxystyryl)benzene ; 3,5,4'-trimethoxy stilbene ; trimethoxystilbene ; (e)-3,4',5-trimethoxystilbene ; trans-trimethoxyresveratrol ; resveratrol three ether ; trimethoxystibene ; benzene,1,3-dimethoxy-5-[(1e)-2-(4-methoxyphenyl)ethenyl]- ; (e)-3,5,4'-trimethoxystilbene ; stilbene,3,4',5-trimethoxy-, (e)- (8ci) ; tri-o-methylresveratrol ; (e)-1-(4-methoxyphenyl)-2-(3,5-dimethoxyphenyl)ethene ; 3,5,4'-trimethoxy-trans-stilbene ; (e)-2-(3,5-dimethoxyphenyl)-1-(4-methoxyphenyl)ethene ; trimethoxy-trans-stilbene ; trismethoxy resveratrol ; benzene,1,3-dimethoxy-5-[2-(4-methoxyphenyl)ethenyl]-, (e)-

Description

3,5,4'-Trimethoxystilbene, an antiangiogenic agent and permethylated derivative of Resveratrol, has been shown to inhibit endothelial cell proliferation, and cause microtubule disassembly and tubulin depolymerization. It has been reported that this compound induces apoptosis via modulation of mitochondrial functions regulated by reactive oxygen species. Further studies note that 3,5,4'-Trimethoxystilbene causes reactive oxygen species generation in the early stages of the induced apoptosis, preceding cytochrome-c release, caspase activation, and DNA fragmentation.

Suppliers

Santa Cruz Biotechnology, Inc.

201450

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Prices & Availability

Data is processed

Properties for 3,5,4′-Trimethoxystilbene

Molecular Weight:

270.32 g·mol−1

Density:

1.105 g/cm3

Melting point:

57 °C

Boiling point:

423.8 °C at 760 mmHg

Flash point:

144.4 °C

Solubility:

Dichloromethane, Ethyl Acetate

Physical Description:

pale yellow oil

Hazard Statements

GHS05
Corrosive

Corrosive to metals, category 1

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

GHS09
Environmental hazard

Acute hazards to the aquatic environment, category 1
Chronic hazards to the aquatic environment, categories 1, 2
Environmental toxicity, categories 1, 2

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin
R37/38 - Irritating to respiratory system and skin
R41 - Risk of serious damage to eyes
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S39 - Wear eye/face protection
S60 - This material and its container must be disposed of as hazardous waste
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Symbols:

Xi, N

Storage temperature :

?20 °C

Alternative Distributors of [3,5,4′-Trimethoxystilbene]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | Clearsynth Canada INC. | Wanko Chemical Co., Ltd.