2-((3-Trifluoromethyl)phenyl)histamine dimaleate has been found to be the most potent and selective H1 histamine receptor agonist of a panel of compounds in functional in vitro studies on histamine H2, H3, and other neurotransmitter receptors. It showed better potency at the guinea pig H1 histamine receptor than at the human H1 histamine receptor (pKi = 5.9). The selectivity of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be 2138 (H1:H2), > 64 (H1:H3), 1000 (H1:M3), 105 (H1: α1), 708 (H1:β1), and 71 (H1:5HT2A). This substance does not cross the blood-brain barrier.
Properties for 2-((3-Trifluoromethyl)phenyl)histamine dimaleate
Molecular Weight:
487.38 g·mol−1
Melting point:
227° C
Solubility:
H2O: ~20 mg/mL
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Safety & Transport Information
Risk Codes:
R25 - Toxic if swallowed R37/38 - Irritating to respiratory system and skin R41 - Risk of serious damage to eyes
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S39 - Wear eye/face protection S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 3
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Alternative Distributors of [2-((3-Trifluoromethyl)phenyl)histamine dimaleate]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.