Treprostinil | CAS 81846-19-7 | Chemical-Suppliers

Element: treprostinil

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C-S » Chemicals » treprostinil-PX78422

Identification

Treprostinil

CAS:

81846-19-7

EINECS:

Molecular Formula:

C₂₃H₃₄O₅

MDL:

MFCD00888847

SMILES:

CCCCC[C@@H](CC[C@H]1[C@@H](C[C@H]2[C@@H]1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O

Synonym:

remodulin ; 15au81 ; acetic acid, (((1r,2r,3as,9as)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3s)-3-hydroxyoctyl)-1h-benz(f)inden-5-yl)oxy)-, monosodium salt ; treprostinil sodium intermediate ; treprostinil [usan:inn] ; treprostinil sodium ; u 62840 ; ((2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3s)-3-hydroxyoctyl)-1h-benz(f)inden- 5-y ; 289480-64-4 ; ((1r,2r,3as,9as)-2-hydroxy-1-((3s)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1h-cylopent(b)naphthalen-5-yl)oxy)acetate ; [[(1r,2r,3as,9as)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3s)-3-hydroxyoctyl]-1h-benz[f]inden-5-yl]oxy]acetic acid ; lrx 15 ; [1r-[1α(s*),2β,3aα,9aα]]- ; 15au-81 ; uniprost ; acetic acid, ((2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-(3-hydroxyoctyl)-1h-benz(f)inden-5-yl)oxy)-, (1r-(1alpha(s*),2beta,3aalpha,9aalpha))- ; acetic acid,[[(1r,2r,3as,9as)-2,3,3a,4,9,9ahexahydro- 2-hydroxy-1-[(3s)-3-hydroxyoctyl]- 1h-benz[f]inden-5-yl]oxy]- ; ut-15 ; [[[(1r)-2,3,3aβ,4,9,9aβ-hexahydro-2α-hydroxy-1-[(s)-3-hydroxyoctyl]-1h-benz[f]inden]-5-yl]oxy]acetic acid ; [[(1r,2r,3as,9as)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(s)-3-hydroxyoctyl]-1h-benzo[f]indene-5-yl]oxy]acetic acid ; treprostinil

Description

Treprostinil is a stable analog of prostacyclin. Treprostinil is used clinically for the treatment of primary pulmonary hypertension (PPH). PPH is characterized by increasing pulmonary arterial and vascular resistance, and the cause is unknown. The structural modifications in treprostinil compared to prostacyclin increase the plasma half-life from 2 minutes to 34 and 85 minutes for intravenous and subcutaneous infusion of the drug, respectively. In addition to treprostinil's direct vasodilatory effects, it also inhibits inflammatory cytokine (TNFα, IL-1β, IL-6, GM-CF) production by human alveolar macrophages in the sub-micromolar range by preventing NF-κB translocation to the nucleus.

Suppliers

Aozeal Certified Standards (AOCS), Inc.

T0117.01

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI8283312

Shandong Ench Chemical Co.,Ltd

SECC3601800

Aea.ltd

A84168

Chemlyte Solutions

CS216648

Pharmacore Co., Limited

PL276828

Hefei Hirisun Pharmatech Co., Ltd

HR131299

BOC Sciences

BS144432

Amadis Chemical Company Limited

ACCL3721860

Santa Cruz Biotechnology, Inc.

205533

Dayang Chem (Hangzhou) Co.,Ltd.

DC3721488

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2-(((1R,2R,3aS,9aS)-2-Hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid

BLD Pharmatech Ltd

BP46872140616

Prices & Availability

Data is processed

Properties for Treprostinil

Molecular Weight:

390.5131 g·mol−1

Density:

1.158 g/cm3

Melting point:

230.04° C (Predicted)

Boiling point:

587.1 °C at 760 mmHg

Flash point:

199.3 °C

Solubility:

Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~30 mg/ml), and DMF:PBS (pH 7.2, 1:1) (~0.5 mg/ml). Insoluble in water at 25 ºC.

Safety & Transport Information

coming up soon

Alternative Distributors of [Treprostinil]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

All Right Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Clearsynth Canada INC.