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Trapoxin A

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Formula: C34H42 N4 O6
CAS: 133155-89-2
search Element: trapoxin

Identification

Structural Formula
Trapoxin A
CAS:
133155-89-2
EINECS:
Molecular Formula:
C34H42 N4 O6
MDL:
SMILES:
C1CCN2[C@H](C1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C2=O)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCCCC(=O)[C@@H]5CO5
Synonym:
cyclo[l-phe-l-phe-d-hpr-6-[2-[(s)-oxiranyl]-2-oxoethyl]-l-nle-] ; trapoxin a ; cyclo((s)-phenylalanyl-(s)-phenylalanyl-(r)-pipecolinyl-(2s,9s)-2-amino-8-oxo-9,10-epoxydecanoyl) ; (4ar,7s,10s,13s)-10,13-dibenzyl-7-[6-oxo-6-[(s)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4ah-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6h,7h,12h,13h)-tetrone ; cyclo[(s)-h-oxo-l-a-aminooxiraneoctanoyl-l-phenylalanyl-l-phenylalanyl-d-2-piperidinecarbonyl] ; 2h-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine, cyclic peptide deriv. ; cyclo[(as,2s)-a-amino-h-oxo-2-oxiraneoctanoyl-l-phenylalanyl-l-phenylalanyl-(2r)-2-piperidinecarbonyl] ; rf 1023a ; rf-1023a ; cyclo[(as,2s)-a-amino-h-oxooxiraneoctanoyl-l-phenylalanyl-l-phenylalanyl-(2r)-2-piperidinecarbonyl](9ci)


Description

Trapoxin A is a cyclotetrapeptide and an HDAC (histone deacetylase) inhibitor. Trapoxin increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin irreversibly inhibits HDAC activity in crude cell lysates and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.


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Properties for Trapoxin A

Molecular Weight:
602.72 g·mol−1
Density:
1.27 g/cm3
Boiling point:
928.3°C at 760 mmHg
Flash point:
515.2°C
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Safety & Transport Information

Risk Codes:
R25 - Toxic if swallowed
Safety Codes:
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T
Hazard symbol T
Storage temperature :
?20 °C
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Alternative Distributors of [Trapoxin A]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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