5-trans U-46619

U-46619 is a TP receptor agonist that exhibits properties similar to Thromboxane A2, inducing platelet aggregation and vascular smooth muscle contraction. This is a minor impurity (2-5%) that is variably present in most commercial preparations of U-46619. The biological activity of 5-trans U-46619 has rarely been tested separately from U-46619 itself. The only case published to date, 5-trans U-46619 was found to be half as potent of an inhibitor of Prostaglandin E synthase as the 5-cis version of U-46619.