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TPCK

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Formula: C17H18ClNO3S
CAS: 402-71-1
search Element: tpck
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Identification

Structural Formula
TPCK
CAS:
402-71-1
EINECS:
206-954-6
Molecular Formula:
C17H18ClNO3S
MDL:
MFCD00000935
SMILES:
CC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CC=CC=C2)C(=O)CCl
Synonym:
tosylphenylalanylchloromethylketone ; n-alpha-tosyl-phe chloromethyl ketone ; tosylphenylalanylchloromethane ; n-tosyl-phe-chloromethylketone ; tos-phe-chloromethylketone ; tpck ; tosyl-l-phenylalanyl-chloromethane ; tos-l-phe-chloromethane ; (-)-p-toluenesulfonamid ; tos-phe-cmk


Description

TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine protease and cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease. Alkylation of IκB kinase beta with TPCK inhibits NF-κB activation, which has been reported to block association of NF-κB to the promoter region for COX-2 transcription, attenuating COX-2 activity. TPCK has also been reported to suppress p53-mediated apoptosis. TPCK is an inhibitor of CTRL. TPCK is an inhibitor of Granzyme.


Suppliers

Acinopeptide Co., Ltd.
A88176
AK Scientific, Inc.
AS76228
+
Santa Cruz Biotechnology, Inc.
201297
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Prices & Availability




Data is processed


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Properties for TPCK

Molecular Weight:
351.85 g·mol−1
Density:
~1.3 g/cm3 (Predicted)
Melting point:
106-108 °C(lit.)
Boiling point:
~509.90° C at 760 mmHg (Predicted)
Solubility:
DMSO: >10 mg/mL stable for several months at 4 °C.
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Safety & Transport Information

Risk Codes:
R37/38 - Irritating to respiratory system and skin
R41 - Risk of serious damage to eyes
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
-20°C
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Alternative Distributors of [TPCK]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Rif Life Science Co., Limited

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Downloads

Mol File:
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MSDS:
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