Tozasertib | CAS 639089-54-6 | Chemical-Suppliers

Element: tozasertib

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C-S » Chemicals » tozasertib-PX94614

Identification

Tozasertib

CAS:

639089-54-6

EINECS:

Molecular Formula:

C₂₃H₂₈N₈OS

MDL:

MFCD13185152

SMILES:

CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

Synonym:

mk 0457 ; tozasertib/vx-680 ; tozasertib(mk-0457,vx-680) ; tozasertib free base ; vx-680/mk-0457 ; vx 680 ; tozasertib ; vx-680(tozasertib) ; tozasertibï¿¡vx680ï¿¡mk0457 ; l-001281814

Description

Tozasertib is a potent pan-ARK inhibitor but favors ARK-1 (K_i = 0.6 nM) over ARK-2 (K_i = 18 nM) or ARK-3 (K_i = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. Tozasertib effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC₅₀ < 10μM), inhibiting H3 histone phosphorylation and increasing apoptosis. By depleting ARK activity, tozasertib disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G₂/M phase.

Suppliers

Ambeed, Inc.

A153482

H&Z Industry Co.,Ltd

HIC200800

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Aea.ltd

A70140

CSNpharm, Inc.

CSN12326

Simagchem Corporation

SC210630

BOC Sciences

BS120360

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

358750

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CAS equal suppliers

VX-680

Capot Chemical Co., Ltd.

22451

VX-680

Haihang Industry Co., Ltd.

HI156468

VX-680

Aea.ltd

A4284

MK 0457

Aea.ltd

A4998

VX-680; Tozasertib; MK-0457

Excenen Pharmatech Co., Ltd.

EX-A2179

N-(4-(4-(5-Methyl-1H-pyrazol-3-ylamino)-6-(1-methylpiperidin-4-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC110862

Tozasertib;Cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino) -pyrimidin-2ylsulphanyl]-phenyl}-amide;VX-680/MK-0457

3B (Wuhan) Scientific Corporation

399693299079

Prices & Availability

Data is processed

Properties for Tozasertib

Molecular Weight:

464.59 g·mol−1

Density:

~1.41 g/cm³ (Predicted)

Melting point:

168-174 °C

Solubility:

Soluble in plain water (10-30 µM), DMSO (100 mg/ml), ethanol (<1 mg/ml) at 25 °C, and methanol.

Safety & Transport Information

coming up soon

Alternative Distributors of [Tozasertib]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

-/-

MSDS:

-/-

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Tozasertib?VX-680? MK-0457)

VX-680; Tozasertib; MK-0457

Tozasertib;Cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino) -pyrimidin-2ylsulphanyl]-phenyl}-amide;VX-680/MK-0457