HC Toxin | CAS 83209-65-8 | Chemical-Suppliers

Element: toxin

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C-S » Chemicals » toxin-PX70514

Identification

HC Toxin

CAS:

83209-65-8

EINECS:

Molecular Formula:

C₂₁H₃₂N₄O₆

MDL:

MFCD00133388

SMILES:

CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3

Synonym:

cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine) ; cyclo(aoe-pro-ala-ala) ; hc toxin i ; cyclic(l-alanyl-d-alanyl-eta-oxo-l-alpha-aminooxiraneoctanoyl-d-prolyl) ; cyclo[d-pro-l-ala-d-ala-2-(6-oxo-6-oxiranylhexyl)-l-gly-] ; cyclo-(d-pro-l-ala-d-ala-l-2-amino-8-oxo-9,10-epoxydecanoic acid) ; toxin i ; cyclo[l-ala-d-ala-[(2s)-2-amino*-8-oxo-8-oxiranyloctanoyl]-d-pro-] ; hc toxin from helminthosporium carbonum ; hc toxin

Description

HC Toxin is a potent, cell-permeable HDAC (histone deacetylase) inhibitor. HC Toxin inhibits HDACs in maize, Physarum and chicken. HC Toxin has displayed antiprotozoal and antineoplastic activity. HC toxin has induced the expression of the gamma-globin gene in erythroid cells. Antiproliferative activity against T47D human breast cancer cells and cultured mastocytoma cells has been observed with HC toxin treatment.