Tolbutamide | CAS 64-77-7 | Chemical-Suppliers

Element: tolbutamide

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C-S » Chemicals » tolbutamide-PX78140

Identification

Tolbutamide

CAS:

64-77-7

EINECS:

Molecular Formula:

C₁₂H₁₈N₂O₃S

MDL:

MFCD00027169

SMILES:

CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Synonym:

irkg ; diasulfon ; d 860 ; tolbutamid ; irk16 ; n-butyl-n'-p-toluenesulfonylurea ; tolbusal ; glyconon ; artosin ; n-(4-methylbenzenesulfonyl)-n'-butylurea ; n-butyl-n'-(p-tolylsulfonyl)urea ; orabet ; urea,1-butyl-3-(p-tolylsulfonyl)- (8ci) ; orezan ; diabetol ; butamid ; drabet ; hls831 ; n-(p-methylbenzenesulfonyl)-n'-butylurea ; dolipol ; tolumide ; 1-butyl-3-(p-methylphenylsulfonyl)urea ; hls 831 ; benzenesulfonamide,n-[(butylamino)carbonyl]-4-methyl- ; toluina ; oralin ; n-butyl-n'-(4-methylphenylsulfonyl)urea ; bz 55 ; nsc 87833 ; rastinon ; aglicid ; tolbutamide ; diabuton ; artozin ; 1-butyl-3-(p-tolylsulfonyl)urea ; diabetamid ; n-n-butyl-n'-tosylurea ; tolumid ; diaben ; willbutamide ; toluvan ; orinase ; n-(4-methylphenylsulfonyl)-n'-butylurea ; d860 ; oterben ; 3-(p-tolyl-4-sulfonyl)-1-butylurea ; girk4 ; n-(sulfonyl-p-methylbenzene)-n'-n-butylurea ; ipoglicone ; u2043 ; arkozal ; orinaz ; mobenol ; pramidex ; n-(p-tolylsulfonyl)-n'-butylcarbamide ; butamide ; u 2043 ; nsc 23813

Description

Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic β-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide's cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and glucagon in the absence of glucose. in all situations the loss of Ca²⁺ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.

Suppliers

Ambeed, Inc.

A315619

Aozeal Certified Standards (AOCS), Inc.

T0052.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI7593036

B.M.P. Bulk Medicines & Pharmaceuticals GmbH

BBMP4842420

Hainan Zhongxin Chemical Co., Ltd.

HZC3741496

CSNpharm, Inc.

CSN12105

Sigma-Aldrich International GmbH

SI3521056

Santa Cruz Biotechnology, Inc.

203298

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

Tolbutamide-d9

Salsbury Chemicals, Inc.

SC3361008

Tolbutamide, 98%

Alfa (A Johnson Matthey Company)

A5121536

N-(Butylcarbamoyl)-4-methylbenzenesulfonamide

BLD Pharmatech Ltd

BP32409720

Benzenesulfonamide, n-[(butylamino)carbonyl]-4-methyl-

Angene International Limited

AGN-PC-09QZS4

Prices & Availability

Data is processed

Properties for Tolbutamide

Molecular Weight:

270.38 g·mol−1

Density:

1.184 g/cm3

Melting point:

128-130°C

Boiling point:

white crystalline powder

Solubility:

Soluble in DMSO or 100% ethanol; insoluble in water.

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36 - Irritating to eyes
R40 - Limited evidence of a carcinogenic effect
R43 - May cause sensitisation by skin contact

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Symbols:

F, Xn

Storage temperature :

Refrigerator

Alternative Distributors of [Tolbutamide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified