TNP-ATP triethylammonium salt | CAS 61368-63-6

Element: triethylammonium salt

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C-S » Chemicals » tnp-atp-triethylammonium-salt-PX82290

Identification

TNP-ATP triethylammonium salt

CAS:

61368-63-6

EINECS:

Molecular Formula:

C₂₂H₁₄LiN₁₁Na₃O₂₅P₃

MDL:

MFCD08669665

SMILES:

CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])O)[C@H]2OC3(O[C@@H]12)C(=CC(=[N+]([O-])[O-])C=C3[N+](=O)[O-])[N+](=O)[O-]

Synonym:

2',3'-o-(2,4,6-trinitrophenyl)adenosine5'-triphosphate ; 2',3'-o-(2,4,6-trinitro-cyclohexadienylidine)adenosine5'-triphosphate ; tnp-atp monolithium trisodium salt ; 2',3'-o-(2,4,6-trinitrophenyl)adenosine-5'-triphosphate trilithium disodium salt ; spiro[cyclohexane-1,2'-furo[3,4-d][1,3]dioxole],adenosine 5'-(tetrahydrogen triphosphate) deriv. ; 2',3'-o-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate monolithium trisodium salt ; tnp-atp ; adenosine5'-(tetrahydrogen triphosphate),2',3'-o-(2,4,6-trinitro-2,4-cyclohexadien-1-ylidene)-, ion(5-) ; 2',3'-o-(2,4,6-trinitrophenyl)-atp ; 2',3'-o-(2,4,6-trinitrophenyl)adenosine-5'-triphosphatetetra(triethylammonium)salt ; 2',3'-o-(2,4,6-trinitrophenyl)adenosine-5'-triphosphate ; tnp-atp hydrate

Description

TNP-ATP triethylammonium salt is a selective P2X receptor antagonist which inhibits ATP-induced currents in cells, specifically P2X1, P2X3 and heteromeric P2X2/3 receptors. In addition, studies show that TNP-ATP triethylammonium salt is 1000 times more selective towards P2X2 receptors than P2X4 and P2X7. Alternate studies indicate that TNP-ATP triethylammonium salt is more potent than TNP-AMP at reducing acetic acid-induced nociception in mice. Furthermore, TNP-ATP triethylammonium salt competes with &alpha,&beta-meATP to bind to the P2X receptors once both ligands reach a steady state condition. Also TNP-ATP triethylammonium salt can be used as a probe to detect the nucleotide binding site of CheA which upon binding results in an inhibition of autophosphorylation.