TGF-β RI Kinase Inhibitor VII | CAS 666729-57-3

Element: inhibitor kinase beta

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C-S » Chemicals » tgf-beta-kinase-inhibitor-vii-PX92410

Identification

TGF-β RI Kinase Inhibitor VII

CAS:

666729-57-3

EINECS:

Molecular Formula:

C₂₁H₂₁NO₄

MDL:

SMILES:

C1=C(C(=CC2=C1C(=CC=N2)OC3=CC(=C(C=C3C(C)=O)C)C)OC)OC

Synonym:

Ethanone, 1-[2-[(6,7-dimethoxy-4-quinolinyl)oxy]-4,5-dimethylphenyl]-

Description

TGF-β RI Kinase Inhibitor VII is a cell-permeable quinoline compound which has been reported to act as a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity, while inhibiting c-Src only at higher concentrations. It has been additionally reported to block Smad2/3 transcription activity and TGF-β-induced Smad2 phosphorylation in human lung cancer epithelial cell line A549.