Terbinafine hydrochloride | CAS 78628-80-5

Element: hydrochloride terbinafine

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Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » terbinafine-hydrochloride-PX71932

Identification

Terbinafine hydrochloride

CAS:

78628-80-5

EINECS:

Molecular Formula:

C₂₁H₂₅N.HCl

MDL:

MFCD00145430

SMILES:

Cl.CN(CC=CC#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1

Synonym:

brican ; bricyn ; brethin ; afogan ; muzonal ; lamisil ; bricar ; lamosil ; kelger ; d02219

Description

Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Research has shown that Terbinafine also reduces the ability of fungal pathogens to generate reactive oxygen species, therefore it is noted as a free radical scavenger in vitro and could potentially contain anti-inflammatory activity in vivo. Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed. Assays further demonstrated that Terbinafine also contains anti-angiogenic effects in chick embryo chorioallantoic membranes. Provided is this product in the hydrochloride form.

Suppliers

Nantong Xindao Biotech Ltd

NXB13005200

XD BIOCHEMS Ltd

XB7502250

FUDI Chemical Co. Ltd.

FCC11004400

Chemlyte Solutions

CS9002700

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI345013800

Shandong Ench Chemical Co.,Ltd

SECC15007500

Autech Industry Co.,Limited

AIC13505400

H&Z Industry Co.,Ltd

HIC10004000

Aea.ltd

A350700

Shandong SanYoung Industry Co., Ltd

SSI17507000

ACIC Fine Chemicals Inc.

AFC12004800

Chenghui Pharmaceutical Group Zone

CPGZ17008500

U-Chemo Scientific (Shanghai) Co.,Ltd.

US19007600

X´ian Taicheng Chem Co., Ltd

XTC14505800

Xiamen Equation Chemical Co.,Ltd

XECC16008000

Sancai Industry Co.,Ltd.

SIC12004800

Arakato Development Ltd

AD11503450

Aecochem Corp.

AC7002100

Hangzhou Keying Chem Co., Ltd.

HKC15006000

Finetech Industry Limited

FIL12505000

Carbone Scientific Co., Ltd.

CS14004200

BOC Sciences

BS6001800

Amadis Chemical Company Limited

ACCL15507750

Santa Cruz Biotechnology, Inc.

200751

Dayang Chem (Hangzhou) Co.,Ltd.

DC15506200

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Chemos GmbH & Co. KG

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Prices & Availability

Data is processed

Properties for Terbinafine hydrochloride

Molecular Weight:

327.89 g·mol−1

Melting point:

204-208 °C

Boiling point:

417.9° C at 760 mmHg

Solubility:

Soluble in methanol, ethanol (~30 mg/ml), methylene chloride, DMSO (~10 mg/ml), DMF (~10 mg/ml), and 1:2 solution of ethanol:PBS (pH 7.2) (0.3 mg/ml). Insoluble in water.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S60 - This material and its container must be disposed of as hazardous waste
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Symbols:

Xi, N

Storage temperature :

-20 °C Freezer

RID/ADR certification :

UN 3077 9 / PG 3

Alternative Distributors of [Terbinafine hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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