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TEMPOL

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Formula: C9H18NO2 *
CAS: 2226-96-2
search Element: tempol
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Identification

Structural Formula
TEMPOL
CAS:
2226-96-2
EINECS:
218-760-9
Molecular Formula:
C9H18NO2 *
MDL:
MFCD00006478
SMILES:
CC1(CC(CC(N1[O])(C)C)O)C
Synonym:
tanol ; tmpn ; 4-oh-tempo ; nr1 ; zj-701 ; hydroxy-tempo ; nitroxyl2 ; tempol ; nr-i ; 4-oxypiperidol


Description

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


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Ambeed, Inc.
A137942
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CSNpharm, Inc.
CSN18690
Santa Cruz Biotechnology, Inc.
200825
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Prices & Availability




Data is processed


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Properties for TEMPOL

Molecular Weight:
172.24 g·mol−1
Density:
1.19 g/cm3
Melting point:
69-71 °C(lit.)
Boiling point:
269° C
Solubility:
Soluble in water (1670 g/l) at 20° C, ethanol (100 mM), methanol, and DMSO (100 mM).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R36/38 - Irritating to eyes and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S27 - Take off immediately all contaminated clothing
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S37/39 - Wear suitable gloves and eye/face protection
Hazard Symbols:
Xn, Xi
Hazard symbol Xn Hazard symbol Xi
Storage temperature :
2-8°C
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Alternative Distributors of [TEMPOL]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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