Tamoxifen Citrate | CAS 54965-24-1

Element: tamoxifen citrate

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C-S » Chemicals » tamoxifen-citrate-PX80285

Identification

Tamoxifen Citrate

CAS:

54965-24-1

EINECS:

259-415-2

Molecular Formula:

C₂₆H₂₉NO.C₆H₈O₇

MDL:

MFCD00058321

SMILES:

CC/C(=C(C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Synonym:

txndc ; adopan ; tmx1 ; terimon ; tmx ; kessar ; noltam ; txndc1 ; tamofen ; zemide

Description

Tamoxifen Citrate is a potent and selective inhibitor of PKC (protein kinase C). It is known that Tamoxifen Citrate functions in PKC ε translocation. Studies suggest that Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Once bound to the estrogen receptor Tamoxifen Citrate will not allow any other ligand to bind to the receptor. In contrast, Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Studies indicate Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

Suppliers

Chemlyte Solutions

CS6121836

H&Z Industry Co.,Ltd

HIC6802720

Aozeal Certified Standards (AOCS), Inc.

T0074.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI23469384

Shandong Lanhai Industry Co.,Ltd.

SLIC11225610

Aea.ltd

A238476

EXCELLA GmbH

E408816

Chemische Fabrik Berg GmbH

CFB8843536

AXO Industry SA

AIS5102040

Alfa (A Johnson Matthey Company)

A10883264

BoomKing Industrial Co.,Limited

BIC10544216

Sancai Industry Co.,Ltd.

SIC8163264

Aecochem Corp.

AC4761428

Hangzhou Keying Chem Co., Ltd.

HKC10204080

Wanko Chemical Co., Ltd.

WC8162448

Sigma-Aldrich International GmbH

SI10883264

scienTEST - bioKEMIX GmbH

S-B8503400

Finetech Industry Limited

FIL8503400

AK Scientific, Inc.

AS6461938

Xingrui Industry Co., Limited

XIL9863944

BOC Sciences

BS4081224

Amadis Chemical Company Limited

ACCL10545270

Leap Chem Co., Ltd

LC6121836

Santa Cruz Biotechnology, Inc.

203288

Dayang Chem (Hangzhou) Co.,Ltd.

DC10544216

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CAS equal suppliers

Tamoxifene citrate

Simagchem Corporation

SC7562268

Tamoxifen citrate, 98%

Acros Organics BVBA

AOB8363344

Prices & Availability

Data is processed

Properties for Tamoxifen Citrate

Molecular Weight:

563.64 g·mol−1

Melting point:

140-144 °C

Boiling point:

482.3° C at 760 mmHg (Predicted)

Solubility:

Soluble in methanol (50 mg/ml with heat) or ethanol (10 mg/ml with sonication); very slightly soluble in water (0.3 mg/L @ 20°C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/ml @ 37°C)4, acetone ,chloroform,and DMSO(100mM)

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R45 - May cause cancer
R60 - May impair fertility
R61 - May cause harm to the unborn child
R64 - May cause harm to breast-fed babies

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use

Hazard Classes:

irritant

Hazard Symbols:

T, Xi

Storage temperature :

2-8°C

Alternative Distributors of [Tamoxifen Citrate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

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MSDS:

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