Tacrine hydrochloride | CAS 1684-40-8

Element: hydrochloride tacrine

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C-S » Chemicals » tacrine-hydrochloride-PX263042

Identification

Tacrine hydrochloride

CAS:

1684-40-8

EINECS:

216-867-5

Molecular Formula:

C₁₃H₁₄N₂ . HCl

MDL:

MFCD00150067

SMILES:

C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl

Synonym:

hydroaminacrine ; ci970 ; romotal dihydrate ; tacrine hcl ; tha dihydrate ; romotal ; cognex ; tenakrin ; tenakrin dihydrate ; tacrine

Description

Tacrine Hydrochloride has been shown to reversibly inhibit acetylcholine esterase (AChE). This compound has been reported to display hepatotoxicity, more specifically causing pericentral necrosis and fat degeneration of hepatocytes. Additionally, tacrine hydrochloride has demonstrated the ability to cause a decrease in liver glycogens and an increase in Heme Oxygenase 1. Other experiments suggest that tacrine hydrochloride causes functional and morphological changes in the endoplasmic reticulum, ribosome, and mitochondria of the liver via DNA synthesis impairment. Tacrine hydrochloride is an inhibitor of butyrylcholinesterase (BChE).

Suppliers

Ambeed, Inc.

A205226

H&Z Industry Co.,Ltd

HIC8403360

CM Fine Chemicals

CFC7142856

Santa Cruz Biotechnology, Inc.

200172

Dayang Chem (Hangzhou) Co.,Ltd.

DC13025208

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CAS equal suppliers

Tacrine HCl

CSNpharm, Inc.

CSN12024

1,2,3,4-Tetrahydroacridin-9-amine hydrochloride

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC106901

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

Santa Cruz Biotechnology, Inc.

sc-214429

Prices & Availability

Data is processed

Properties for Tacrine hydrochloride

Molecular Weight:

234.72 g·mol−1

Melting point:

280-284 °C(lit.)

Solubility:

Soluble in water (25 mg/ml), ethanol, PBS (pH 7.2) (~16 mg/ml), and methanol. Insoluble in DMSO, and DMF.

Safety & Transport Information

Risk Codes:

R20/22 - Harmful by inhalation and if swallowed
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(a)

Hazard Symbols:

T, Xn

Storage temperature :

2-8°C

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Tacrine hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Watson International Ltd | Clearsynth Canada INC.

Downloads

Mol File:

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MSDS:

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