Sunitinib malate | CAS 341031-54-7

Element: sunitinib malate

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C-S » Chemicals » sunitinib-malate-PX382602

Identification

Sunitinib malate

CAS:

341031-54-7

EINECS:

Molecular Formula:

C₂₂H₂₇FN₄O₂.C₄H₆O₅

MDL:

MFCD08282795

SMILES:

CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O

Synonym:

(2s)-2-hydroxybutanedioic acid ; malic acid shu ; 1h-pyrrole-3-carboxamide, n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-, (2s)-hydroxybutanedioate (1:1) ; sunitinib mablate ; sunitinib malate(tinibs) ; n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dih ; ezsolution sunitinib malate ; butanedioic acid, hydroxy-, (2s)-, compd. with n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide (1:1) ; su 011248 ; su011248 l-malate salt ; sunitinib malate ; sunitinib malate(sutent) ; pha-290940ad ; su010398 ; butanedioic acid, 2 ; sunitinib malate(su 11248) ; su112248 ; sunitinib malate [usan] ; n-(2-diethylaminoethyl)-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide

Description

Sunitiba Malate is an antineoplastic agent and a potent RTK inhibitor which includes Flk-1 (VEGFR2) as a primary target. It also is a potent, ATP-competitive inhibitor of VEGFR, PDGFR-β and c-Kit (KIT). Sunitiba Malate inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models. Sunitinib Malate is an inhibitor of c-Fms-CSF-1R, Flt-1, Flt-3/Flk-2, Flt-4, PDGFR-α and Ret.

Suppliers

Ambeed, Inc.

A142950

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI22088832

H&Z Industry Co.,Ltd

HIC6402560

Aea.ltd

A224448

Shandong SanYoung Industry Co., Ltd

SSI11204480

Chemlyte Solutions

CS5761728

Arcadia Biotechnology

AB6722016

CSNpharm, Inc.

CSN12411

Finetech Industry Limited

FIL8003200

Hefei Hirisun Pharmatech Co., Ltd

HR013251

CM Fine Chemicals

CFC5442176

Capot Chemical Co., Ltd.

29941

Zehao Industry Co., Ltd.

ZI7682304

BOC Sciences

BS3841152

Amadis Chemical Company Limited

ACCL9924960

Leap Chem Co., Ltd

LC5761728

Santa Cruz Biotechnology, Inc.

220177

Dayang Chem (Hangzhou) Co.,Ltd.

DC9923968

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CAS equal suppliers

(Z)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (S)-2-hydroxysuccinate

BLD Pharmatech Ltd

BP43416130248

N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate

Acinopeptide Co., Ltd.

A66000132000

N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate

Autech Industry Co.,Limited

AIC81000324000

N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate

BoomKing Industrial Co.,Limited

BIC93000372000

N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate

Zehao Industry Co., Ltd.

ZI72000216000

Prices & Availability

Data is processed

Properties for Sunitinib malate

Molecular Weight:

532.566 g·mol−1

Melting point:

189-191 °C

Boiling point:

572.1 °C at 760 mmHg

Flash point:

299.8 °C

Solubility:

Soluble in water (>25 mg/ml, pH 1.2-6.8), DMSO (>10 mg/ml), and methanol.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R2 - Risk of explosion by shock, friction, fire or other sources of ignition
R48/25 - Toxic: danger of serious damage to health by prolonged exposure if swallowed
R61 - May cause harm to the unborn child

Safety Codes:

S22 - Do not breathe dust
S36/37 - Wear suitable protective clothing and gloves
S53 - Avoid exposure - obtain special instructions before use

Hazard Symbols:

Storage temperature :

Store at +4 °C

Alternative Distributors of [Sunitinib malate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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MSDS:

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