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Stat3 inhibitor V, stattic

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Formula: C8H5 N O4 S
CAS: 19983-44-9

Identification

Structural Formula
Stat3 inhibitor V, stattic
CAS:
19983-44-9
EINECS:
Molecular Formula:
C8H5 N O4 S
MDL:
MFCD00173799
SMILES:
C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
Synonym:
1,1-dioxo-6-nitrobenzo(b)thiophene ; 6-nitro-1-benzothiophene 1,1-dioxide ; stat3 inhibitor v, stattic ; buttpark 97\04-73 ; 6-nitro-1h-1lambda6-benzo[b]thiophene-1,1-dione ; 6-nitrobenzo[b]thiophene1,1-dioxide ; akos 1001 ; benzo[b]thiophene, 6-nitro-, 1,1-dioxide ; stattic ; benzo[b]thiophene,6-nitro-, 1,1-dioxide ; stat three inhibitory compound


Description

Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines, and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3.


Suppliers

Santa Cruz Biotechnology, Inc.
202818
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Prices & Availability




Data is processed


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Properties for Stat3 inhibitor V, stattic

Molecular Weight:
211.19 g·mol−1
Density:
1.621 g/cm3
Melting point:
129.80° C (Predicted)
Boiling point:
461.1°C at 760 mmHg
Flash point:
232.6°C
Solubility:
Soluble in ethanol (5 mM), and DMSO (50 mM). Insoluble in water.
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Symbols:
Xi, Xn
Hazard symbol Xn Hazard symbol Xi
Storage temperature :
Store at +4 °C
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Alternative Distributors of [Stat3 inhibitor V, stattic]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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