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Spironolactone

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Formula: C24H32O4S
CAS: 52-01-7
search Element: spironolactone

Identification

Structural Formula
Spironolactone
CAS:
52-01-7
EINECS:
200-133-6
Molecular Formula:
C24H32O4S
MDL:
MFCD00082250
SMILES:
CC(=O)SC1CC2=CC(=O)CC[C@]2(C)C2CC[C@@]3(C)C(CC[C@@]33CCC(=O)O3)[C@H]12
Synonym:
acelat ; aldopur ; osiren ; altex ; dira ; alderon ; sc9420 ; osyrol ; almatol ; aldace


Description

Spironolactone is a competitive MCR (mineralocorticoid receptor) antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis. Spironolactone is an inhibitor of AR.


Suppliers

Shandong SanYoung Industry Co., Ltd
SSI4901960
Nantong Xindao Biotech Ltd
NXB3641456
Aozeal Certified Standards (AOCS), Inc.
S0033.00
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI9663864
Shandong Minglang Chemical Co., Ltd
SMC4901960
H&Z Industry Co.,Ltd
HIC2801120
Indofine Chemical Co, Inc.
023554
Guangzhou Topwork Chemical Co., Ltd.
GTC5042016
Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT7143570
AXO Industry SA
AIS210840
Alfa (A Johnson Matthey Company)
A4481344
Caesar & Loretz GmbH
CL280840
Xiamen Equation Chemical Co.,Ltd
XECC4482240
Sancai Industry Co.,Ltd.
SIC3361344
Arakato Development Ltd
AD322966
Aecochem Corp.
AC196588
Hangzhou Keying Chem Co., Ltd.
HKC4201680
Sigma-Aldrich International GmbH
SI4481344
scienTEST - bioKEMIX GmbH
S-B3501400
AK Scientific, Inc.
AS266798
Leap Chem Co., Ltd
LC252756
Santa Cruz Biotechnology, Inc.
204294
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CAS equal suppliers

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Acros Organics BVBA
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17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
Chemieliva Pharmaceutical Co., Ltd.
CP2716081480
17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
Wanko Chemical Co., Ltd.
WC1862455872
17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate, spironolactone
Chemlyte Solutions
CS1830654918

Prices & Availability




Data is processed


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Properties for Spironolactone

Molecular Weight:
416.57 g·mol−1
Density:
~1.2 g/cm3 (Predicted)
Melting point:
207-208 °C(lit.)
Boiling point:
~597.0° C at 760 mmHg (Predicted)
Solubility:
Soluble in water (0.022 mg/ml at 25° C), ethanol (50 mM), methanol, DMSO (100 mM), and chloroform (50 mg/ml).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
R40 - Limited evidence of a carcinogenic effect
R60 - May impair fertility
Safety Codes:
S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Symbols:
T, Xn, Xi
Hazard symbol T Hazard symbol Xn Hazard symbol Xi
Storage temperature :
Store at RT
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Alternative Distributors of [Spironolactone]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Santec Chemicals Corp. | Rongkang Industry Co.,Ltd - (NSTU Chemicals Hanggzhou Co.,) | Xiangfan Goto Chemical Co., Ltd. | Ningbo Zhengrun Chemicals Co., Ltd. Exp. Dept. | Molekula GmbH | CCS. CHEM. Co., Ltd. | Shanghai Daishang Chemical Cc., Ltd. | 3B Scientific Corporation | ABCR GmbH & Co. KG | Jinan Great Chemical Co., Ltd. | Afine Chemicals Limited | Nantong Chem-Tech. (Group) Co., Ltd. | Shiva Chemicals & Pharmaceuticals Services Ltd. | TCI Europe NV | Changzhou An-Yuan Imp. & Exp. Corporation | New Dragon Industrial Co., Ltd | Orichem International Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai AOKChem Group Limited | Wuhan Yuancheng Chemical Group Co., Ltd | Suzhou Rovathin Pharmatech Co., Ltd | Shiva Chemicals and Pharmaceuticals Services Limited | Hangzhou Think Chemical Co., Ltd. | Lanospharma Laboratories Co., Ltd. | TCS INDUSTRY LTD. | Ningbo Hi-Tech Biochemicals Co., Ltd. | Jinjiangchem Corporation | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Watson International Ltd | Yongyi Chemicals Group Co., Ltd. | Suzhou Bichal Biological Technology Co., Ltd. | Shanxi Jinjin Chemical Co., Ltd. | Varnor Chemical Co.,Limited | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Clearsynth Canada INC. | Wanko Chemical Co., Ltd.

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