Sorafenib | CAS 284461-73-0 | Chemical-Suppliers

Element: sorafenib

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C-S » Chemicals » sorafenib-PX396642

Identification

Sorafenib

CAS:

284461-73-0

EINECS:

Molecular Formula:

C₂₁H₁₆ClF₃N₄O₃

MDL:

MFCD06411450

SMILES:

CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=C1

Synonym:

Description

Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that sorafenib induces c-Raf phosphorylation at both Ser-43 and Ser-259. When combined with vitamin K1, phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that sorafenib inhibits other kinases such as Flk-1 (VEGFR2), PDGFR (platelet-derived growth factor receptor), Flt-3/Flk-2 (FLT3), Ret, and c-Kit. Sorafenib is an inhibitor of Raf-1, Raf-B, PDGFR-βand Flt-4. Its ability to affect the Raf/Mek/Erk pathway makes it useful in cancer research studies.

Suppliers

Ambeed, Inc.

A316727

H&Z Industry Co.,Ltd

HIC180720

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

Shandong SanYoung Industry Co., Ltd

SSI3151260

Aozeal Certified Standards (AOCS), Inc.

S0041.00

Sancai Industry Co.,Ltd.

SIC216864

Aecochem Corp.

AC126378

CSNpharm, Inc.

CSN10381

Hangzhou Keying Chem Co., Ltd.

HKC2701080

Carbone Scientific Co., Ltd.

CS252756

Hefei Hirisun Pharmatech Co., Ltd

HR013455

CM Fine Chemicals

CFC153612

BOC Sciences

BS108324

Amadis Chemical Company Limited

ACCL2791395

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

220125

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Gihi Chemicals Co., Limited

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Chemlyte Solutions

CS1940458212

Prices & Availability

Data is processed

Properties for Sorafenib

Molecular Weight:

464.82 g·mol−1

Density:

~1.5 g/cm³ (Predicted)

Melting point:

202-204° C

Boiling point:

~523.35° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (~20 mg/ml), Hot Methanol, DMF (~20 mg/ml), 1:2 solution of DMSO:PBS(PH 7.2 ) (~0.3 mg/ml), 100% ethanol, and ethyl acetate.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [Sorafenib]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified