MK-886 sodium salt | CAS 118427-55-7

Element: sodium salt

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C-S » Chemicals » sodium-salt-PX69254

Identification

MK-886 sodium salt

CAS:

118427-55-7

EINECS:

Molecular Formula:

C₂₇H₃₄ Cl N O₂ S . Na

MDL:

MFCD11045945

SMILES:

CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)[O-])CC3=CC=C(C=C3)Cl.[Na+]

Synonym:

mk-886 ; mk-886 hydrate sodium salt ; mk 886 sodium salt ; mk-886 sodium hydrate ; 3-[1-(p-chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid,sodium ; mk-886 sodium salt hydrate ; 3-[3-tert-butylthio-1-(4-chlorobenzyl)-5-isopropyl-1h-indol-2-yl]-2,2-dimethylpropionic acid, sodium ; 3-[1-(p-chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, na ; 1h-indole-2-propanoicacid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-, sodium salt (1:1) ; l 663536 sodium salt ; 3-[tert-butylthio-1-(4-chlorobenzyl)-5-isopropyl-1h-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt ; 1h-indole-2-propanoicacid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-, sodium salt (9ci)

Description

MK-886 sodium salt, also designated L-663,536, is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP). FLAP is an arachidonic acid binding protein that is critical in the biosynthesis of leukotrienes. Inhibitors of FLAP prevent translocation of 5-lipoxygenase from the cytosol to the membrane and inhibit 5-lipoxygenase (5-LO) activation. MK-886 binds to FLAP with high affinity and prevents the activation of 5-LO, thus inhibiting leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. MK-886 sodium salt is an inhibitor of Cox-1, PGE Synthase and PPARα.