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SIVELESTAT

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Formula: C20H22N2O7S
CAS: 127373-66-4
search Element: sivelestat
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Identification

Structural Formula
SIVELESTAT
CAS:
127373-66-4
EINECS:
Molecular Formula:
C20H22N2O7S
MDL:
MFCD00889071
SMILES:
CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
Synonym:
sivelestat sodium impurity ; ono 5046 ; ei 546 sodium salt hydrate ; ly 544349 ; ei 546 ; sivelestate ; sivelestat ; sivelestate sodium ; elaspol sodium salt hydrate ; sivelestat (ono-5046)


Description

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 μM). Sivelestat does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 μM. Sivelestat effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability. Sivelestat is also reported to inhibit mast cell Stat6-protease.


Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6902760
+
Simagchem Corporation
SC210630
+
Leap Chem Co., Ltd
LC180540
+
Santa Cruz Biotechnology, Inc.
203938
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Prices & Availability




Data is processed


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Properties for SIVELESTAT

Molecular Weight:
434.46 g·mol−1
Density:
1.37 g/cm3 (Predicted)
Melting point:
218-220° C
Solubility:
Soluble in DMSO.
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Safety & Transport Information

Storage temperature :
room temp
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Alternative Distributors of [SIVELESTAT]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd

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Downloads

Mol File:
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MSDS:
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