Sirtinol | CAS 410536-97-9 | Chemical-Suppliers

Element: sirtinol

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C-S » Chemicals » sirtinol-PX73544

Identification

Sirtinol

CAS:

410536-97-9

EINECS:

Molecular Formula:

C₂₆H₂₂N₂O₂

MDL:

MFCD00810186

SMILES:

CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2N/C=C/3C(=O)C=CC4=CC=CC=C43

Synonym:

sirtinol ; (e)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-n-(1-phenylethyl)benzamide ; 2-[(2-oxonaphthalen-1-ylidene)methylamino]-n-[(1r)-1-phenylethyl]benzamide ; 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-n-(1-phenylethyl)benzamide ; 2-[(2-hydroxynaphthalen-1-ylmethylene)amino]-n-(1-phenethyl)benzamide ; sir two inhibitor naphthol ; 2-{[(2-hydroxynaphthalen-1-yl)methylidene]amino}-n-(2-phenylethyl)benzamide

Description

Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. Sirtinol has been shown to inhibit yeast Sir2 (IC₅₀ = 70 μM), human SIRT2 (IC₅₀ = 40 μM), and human SIRT1 (IC₅₀ = 131 μM), yet has shown no effect on human HDAC1. In Arabidopsis, sirtinol strongly affected root and vascular tissue development by activating the auxin signaling pathway. Sirtinol has also been shown to induce senescence-like growth arrest in human breast cancer MCF-7 and lung cancer H1299 cells by impaired activation of MAPK.

Suppliers

Aea.ltd

A56112

CSNpharm, Inc.

CSN12523

Leap Chem Co., Ltd

LC144432

Santa Cruz Biotechnology, Inc.

205976

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CAS equal suppliers

2-[(E)-(2-hydroxy-1-naphthyl)methyleneamino]-N-(1-phenylethyl)benzamide

Manchester Organics Limited

D36160

{2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide

BLD Pharmatech Ltd

BP894626838

Prices & Availability

Data is processed

Properties for Sirtinol

Molecular Weight:

394.4651 g·mol−1

Density:

1.276 g/cm3

Melting point:

119-120°C

Boiling point:

650°C at 760 mmHg

Flash point:

211.4°C

Solubility:

Soluble in DMSO (100 mM), 100% ethanol, and DMF. Insoluble in water.

Safety & Transport Information

Storage temperature :

-20°C

Alternative Distributors of [Sirtinol]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | Ark Pharm, Inc. | Jinjiangchem Corporation | East Chemical Industry Co., Ltd. | Sino Rarechem Labs Co. Ltd.

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MSDS:

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