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Siomycin A

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Formula: C71H81 N19 O18 S5
CAS: 12656-09-6
search Element: siomycin

Identification

Structural Formula
Siomycin A
CAS:
12656-09-6
EINECS:
Molecular Formula:
C71H81 N19 O18 S5
MDL:
SMILES:
CC=C1C2=NC(CS2)C(=O)NC(C3=NC(=CS3)C(=O)NC4C(OC(=O)C5=NC6=C(C=CC(C6O)NC(C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C(=O)NC7(CCC(=NC7C8=CSC4=N8)C9=NC(=CS9)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C2=NC(=CS2)C(=O)NC(C(=O)N1)C(C)O)C)C(C)C)C(=C5)C(C)O)C)C(C)(C(C)O)O
Synonym:
4)-lactone, (4® ; mutabilycin, sporangiomycin, 6741-21, mutabillicin ; mutabillicin ; siomycin a ; alaninamide,l-threonyl-(4s)-2-[(1z)-1-amino-1-propenyl]-4,5-dihydro-4-thiazolecarbonyl-2-[(1s,2s,3r)-1-amino-2,3-dihydroxy-2-methylbutyl]-4-thiazolecarbonyl-2-[(5r,6s)-6-[2-[(1s,2r)-1-amino-2-hydroxypropyl]-4-thiazolyl]-5-[[n-[(7r,8s)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1s)-1-hydroxyethyl]-7-quinolinyl]-l-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-l-alanyl]amino]-5-(4-carboxy-2-thiazolyl)-3,4,5,6-tetrahydro-2-pyridinyl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-,(1'® ; nsc 285116 ; mutabilycin ; alaninamide,n-[(7r,8s)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1s)-1-hydroxyethyl]-7-quinolinyl]-l-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-l-alanyl-2-[(4ar,11s,14z,18s,21s,28s,32as)-4a-amino-21-[(1s,2r)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1r)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17h,26h-8,5:18,15:25,22:32,29-tetranitrilo-5h,15h-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-dideh ; 1)-lactam (9ci) ; 17h,26h-4a,28-(iminoethaniminoethaniminoethaniminoethanimino[7,2]quinolinomethanoxymethano)-8,5:18,15:25,22:32,29-tetranitrilo-4h,15h-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontine,cyclic peptide deriv. ; antibiotic 6741-21


Description

Siomycin A, an antibiotic thiazole compound, has been shown to down-regulate the mRNA and protein abundance as well as transcriptional activity of transcription factor forkhead box M1 (FoxM1). Consequentially, it was demonstrated that the downstream target genes of FoxM1, such as CENP-B, Survivin, and Cdc25B were repressed. This compound was also reported to induce potent p53-independent apoptosis in cancer cell lines of different origin.


Suppliers

Santa Cruz Biotechnology, Inc.
202339
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Properties for Siomycin A

Molecular Weight:
1648.8 g·mol−1
Solubility:
DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water.
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Safety & Transport Information

Storage temperature :
?20 °C
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Alternative Distributors of [Siomycin A]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH

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