Simvastatin Hydroxy Acid, Ammonium Salt | CAS 139893-43-9

Element: simvastatin ammonium hydroxy acid salt

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Identification

Simvastatin Hydroxy Acid, Ammonium Salt

CAS:

139893-43-9

EINECS:

Molecular Formula:

C₂₅H₄₀O₆.NH₃

MDL:

SMILES:

CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)[O-])O)O)C.[NH4+]

Synonym:

simvastatin carboxylic acid ammonium salt ; simvastatin hydroxy acid, ammonium salt ; tenivastatin ammonium salt ; simvastatin ammonium salt ; simvastatin acid ammonium salt ; simvastatin impurity a ; 1-naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a ; (βr,Î´r,1s,2s,6r,8s,8ar)- ; simvastatin hydroxy acid ammonium salt, >=95% ; simvastatin hydroxyl acid ammonium salt

Description

Simvastatin Hydroxy Acid, is a potent reversible inhibitor of HMGCR (HMG-CoA reductase). This simvastatin metabolite reduces cholesterol synthesis and increases low-density lipoprotein (LDL) receptors on cell membranes of liver and extrahepatic tissues. Studies suggest that simvastatin hydroxy acid can be determined in plasma using liquid chromatography–UV detection (LC–UV) or gas chromatography–mass spectrometry (GC–MS). Further studies have shown that the cytochromes CYP3A4, CYP3A5, and CYP2C8 all catalyz the formation of simvastatin hydroxy acid.

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Santa Cruz Biotechnology, Inc.

208389

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Data is processed

Properties for Simvastatin Hydroxy Acid, Ammonium Salt

Molecular Weight:

453.61 g·mol−1

Melting point:

128-131 °C

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin
R40 - Limited evidence of a carcinogenic effect
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R61 - May cause harm to the unborn child
R64 - May cause harm to breast-fed babies

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S53 - Avoid exposure - obtain special instructions before use

Hazard Symbols:

Xi, T

Storage temperature :

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Alternative Distributors of [Simvastatin Hydroxy Acid, Ammonium Salt]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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