Sildenafil-d3 | CAS 1126745-90-1

Element: sildenafil

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C-S » Chemicals » sildenafil-PX75729

Identification

Sildenafil-d3

CAS:

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Molecular Formula:

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SMILES:

[2H]C([2H])([2H])N1CCN(CC1)S(=O)(=O)C1=CC=C(OCC)C(=C1)C1=NC2=C(N(C)N=C2CCC)C(=O)N1

Synonym:

Description

Sildenafil-d3 is a deuterium-labelled analog of Sildenafil. Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.