Hh Signaling Antagonist VII, JK184 | CAS 315703-52-7

Element: antagonist signaling jk184

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Identification

Hh Signaling Antagonist VII, JK184

CAS:

315703-52-7

EINECS:

Molecular Formula:

C₁₉H₁₈ N₄ O S

MDL:

MFCD01044465

SMILES:

CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C

Synonym:

JK184 ; ; 2-Thiazolamine,N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-

Description

Hh Signaling Antagonist VII, JK184 is an imidazopyridine compound that inhibits the Hedgehog (Hh) signaling pathway. JK184 is described to directly interact with tubulin subunits and prevent their polymerization into filaments, affecting the Hh pathway by destabilizing microtubules and modulating the microtubule-dependent mechanisms regulating function of the Gli transcription factors. JK184 also inhibits ADH7 (alcohol dehydrogenase 7), a function suggested to be ancillary to the effects of JK184 on microtubules and the Hh pathway.

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Santa Cruz Biotechnology, Inc.

202649

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

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Hangzhou MolCore BioPharmatech Co.,Ltd.

MC100602

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Properties for Hh Signaling Antagonist VII, JK184

Molecular Weight:

350.44 g·mol−1

Density:

1.3

Solubility:

soluble to 100 mM in DMSO and to 25 mM in ethanol

Safety & Transport Information

coming up soon

Alternative Distributors of [Hh Signaling Antagonist VII, JK184]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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