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Shikonin

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Formula: C16H16O5
CAS: 517-89-5
search Element: shikonin
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Identification

Structural Formula
Shikonin
CAS:
517-89-5
EINECS:
Molecular Formula:
C16H16O5
MDL:
MFCD00075680
SMILES:
CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
Synonym:
gromwell pigment ; shikonin ; shikonin(as) ; (-)-shikoninchina ; shikonine ; c.i.75535 ; gromweil pigment ; (-)-shikonin ; tokyo violet ; shikonin 98+%


Description

Shikonin is a naturally occurring active chemical found in the root of Lithospermum erythrorhizon and used as a Chinese herb. The compound is a naphthoquinone derivative and has been shown to have anti-inflammatory and anti-tumor properties, as well as alter chemokine expression and function. Angiogenesis studies have shown that Shikonin can inhibit proliferation and migration of endothelial cells, block integrin αvβ3 expression, and inhibit B16 melanoma- and tumor necrosis factor-alpha-inuced angiogenesis in mice. Shikonin can down-regulate protein and mRNA expression of CKR-5 (CCR5), a primary HIV-1 coreceptor, in macrophages in HIV studies. Shikonin is an inhibitor of PKM2.


Suppliers

Chengdu Pufeide Biotech. Co., Ltd
CPB2641056
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI5522208
+
Indofine Chemical Co, Inc.
06-1190
CSNpharm, Inc.
CSN12365
Pharmacore Co., Limited
PL184552
AK Scientific, Inc.
AS152456
+
BOC Sciences
BS96288
+
Leap Chem Co., Ltd
LC144432
+
Santa Cruz Biotechnology, Inc.
200391
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Prices & Availability




Data is processed


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Properties for Shikonin

Molecular Weight:
288.3 g·mol−1
Density:
1.37 g/cm3 (Predicted)
Melting point:
202.18 °C (Predicted)
Boiling point:
567.36 °C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (10 mg/ml).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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Alternative Distributors of [Shikonin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | ABCR GmbH & Co. KG | Jinan Great Chemical Co., Ltd. | SYNCHEM OHG | Scandinavian Formulas, Inc. | Yongyi Chemicals Group Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Chengdu Biopurify Phytochemicals Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | East Chemical Industry Co., Ltd.

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