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SANT-1

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Formula: C23H27 N5
CAS: 304909-07-7
search Element: sant
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Identification

Structural Formula
SANT-1
CAS:
304909-07-7
EINECS:
Molecular Formula:
C23H27 N5
MDL:
MFCD01827306
SMILES:
CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4
Synonym:
1-piperazinamine, n-[(3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl)methylene]-4-(phenylmethyl)- ; (4-benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1h-pyrazol-4-ylmethylene)-amine ; 1-piperazinamine,n-[(3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl)methylene]-4-(phenylmethyl)- ; sant 1 ; sant-1 ; (e)-n-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine ; n-[(3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine


Description

SANT-1 is a membrane permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway by direct binding to Smo. This inhibition of Smo occurs equipotently by SANT-1 binding to both the oncogenic Smo and wild-type. When combined HDAC inhibitor SAHA, SANT-1 was able to suppress cellular proliferation and colony formation of Gemcitabine-resistant pancreatic adenocarcinoma cell lines Panc-1 and BxPC-3.


Suppliers

Aea.ltd
A4284
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CSNpharm, Inc.
CSN19183
Santa Cruz Biotechnology, Inc.
203253
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CAS equal suppliers

(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
Huateng Pharmaceutical Co.,Ltd
92608

Prices & Availability




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Properties for SANT-1

Molecular Weight:
373.49 g·mol−1
Density:
1.13 g/cm3
Melting point:
104-106°C
Boiling point:
547.4°C at 760 mmHg
Flash point:
284.8°C
Solubility:
Soluble in DMSO (50 mM), water (<2 mg/ml), chloroform, methanol, and ethanol (25 mM).
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [SANT-1]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | D&P Global Chemical Co., Ltd

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MSDS:
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