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Sangivamycin

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Formula: C12H15N5O5
CAS: 18417-89-5
search Element: sangivamycin
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Identification

Structural Formula
Sangivamycin
CAS:
18417-89-5
EINECS:
Molecular Formula:
C12H15N5O5
MDL:
MFCD00214391
SMILES:
O.NC(=O)C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C2=C1C(N)=NC=N2
Synonym:
b90912 ; nsc-65346 ; ba-90912 ; sangivamycin ; ski27013 ; 7-deaza-7-carbamoyladenosine ; 7-deazaadenosine-7-carboxamide ; antibiotic ba-90912 ; antibioticb-14437 ; b-14437


Description

Sangivamycin is a cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). Sangivamycin is also a selective and potent PKC (protein kinase C) inhibitor (IC50 = 10μM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors. The phosphorylation of histone H1 protein is a mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers.


Suppliers

Alpha Biopharmaceuticals Co., Ltd.
AB4081224
+
Leap Chem Co., Ltd
LC216648
+
Santa Cruz Biotechnology, Inc.
204261
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Prices & Availability




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Properties for Sangivamycin

Molecular Weight:
309.28 g·mol−1
Boiling point:
880.6° C at 760 mmHg (Predicted)
Solubility:
Soluble in cold water, and 0.1 M KOH.
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Safety & Transport Information

Risk Codes:
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed
Safety Codes:
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T+
Hazard symbol T+
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 2
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Alternative Distributors of [Sangivamycin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH

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Downloads

Mol File:
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MSDS:
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