Salubrinal | CAS 405060-95-9 | Chemical-Suppliers

Element: salubrinal

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » salubrinal-PX66887

Identification

Salubrinal

CAS:

405060-95-9

EINECS:

Molecular Formula:

C₂₁H₁₇ Cl₃ N₄ O S

MDL:

MFCD00548612

SMILES:

C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3

Synonym:

(2e)-3-phenyl-n-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide salubrinal ; sal ; (2e)-3-phenyl-n-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide ; (e)-3-phenyl-n-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide ; 3-phenyl-n-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide ; salubrinal ; 2-propenamide,3-phenyl-n-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-,(2e)- ; salubrinal (2e)-3-phenyl-n-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide ; 2-propenamide, 3-phenyl-n-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2e)-

Description

Salubrinal is a cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC₅₀~15μM) in PC12 cell lines induced with the protein glycosylation inhibitor tunicamycin, and brefeldin A, which causes ER stress by blocking ER-to-Golgi vesicle transport. Salubrinal is a potentially useful agent to study mechanisms of ER stress-induced apoptosis.

Suppliers

Ambeed, Inc.

A591957

Aea.ltd

A70140

Feiming Chemical Limited.

SFC052

Feiming Chemical Limited.

FCL2501000

CSNpharm, Inc.

CSN11888

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

202332

Dayang Chem (Hangzhou) Co.,Ltd.

DC3101240

Get Quick Quote

CAS equal suppliers

2-Propenamide,3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-,(2E)-

CM Fine Chemicals

CFC1649065960

Prices & Availability

Data is processed

Properties for Salubrinal

Molecular Weight:

479.81 g·mol−1

Density:

1.47 g/cm³ (Predicted)

Melting point:

276.03° C (Predicted)

Boiling point:

635.79° C (Predicted)

Solubility:

Soluble in DMSO (96 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (2 mg/ml at 25° C).

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

Hazard Symbols:

Storage temperature :

Store at +4 °C

Alternative Distributors of [Salubrinal]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

D&P Global Chemical Co., Ltd

Downloads

Mol File:

-/-

MSDS:

-/-