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Safingol

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Formula: C18H39NO2
CAS: 15639-50-6
search Element: safingol
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Identification

Structural Formula
Safingol
CAS:
15639-50-6
EINECS:
Molecular Formula:
C18H39NO2
MDL:
MFCD00792847
SMILES:
CCCCCCCCCCCCCCC[C@H]([C@@H](CO)N)O
Synonym:
l-threo-sphinganine, c18 chain ; l-threo-dihydrosphingosine (d18:0) ; l-threo-dihydrosphingosine ; safingol ; l-threo-dihydrospingosine


Description

Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Safingol inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 μM and 31μM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 μM). Safingol enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC) in gastric cancer cells by promoting drug-induced apoptosis. Safingol is an inhibitor of SphK (Sphingosine kinase).


Suppliers

Santa Cruz Biotechnology, Inc.
204258
Dayang Chem (Hangzhou) Co.,Ltd.
DC248992
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CAS equal suppliers

L-Threo-dihydrosphingosine
Salsbury Chemicals, Inc.
SC6241872
L-Threo-dihydrosphingosine
Gihi Chemicals Co., Limited
GCL7022808

Prices & Availability




Data is processed


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Properties for Safingol

Molecular Weight:
301.51 g·mol−1
Density:
~0.9 g/cm3 (Predicted)
Melting point:
106.8-108.7° C
Boiling point:
>300° C
Flash point:
110 °C
Solubility:
Soluble in chloroform, water (partly miscible), DMSO (~2 mg/ml), DMF (~10 mg/ml), ethanol, and methanol.
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [Safingol]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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