Rifampicin | CAS 13292-46-1 | Chemical-Suppliers

Element: rifampicin

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C-S » Chemicals » rifampicin-PX475449

Identification

Rifampicin

CAS:

13292-46-1

EINECS:

236-312-0

Molecular Formula:

C₄₃H₅₈N₄O₁₂

MDL:

MFCD00151389

SMILES:

C[C@H]1/C=C/C=C(C(=O)NC2=C(C3=C(C(=C4C(=C3C(=O)/C2=C/NN5CCN(CC5)C)C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C

Synonym:

rif ; rifadin ; rifinah ; arficin ; rifagen ; rifa ; famcin ; rhof ; arhf ; l-5103

Description

Rifampicin is an antibiotic that potently inhibits RNA polymerase and blocks RNA synthesis in Escherichia coli. The compound has been shown to inhibit α-synuclein fibrillation and disaggregate fibrils in a concentration-dependent manner. Data indicates that Rifampicin can activate the nuclear pregnane X receptor (PXR), which affects cytochrome P450, and the activity of glucuronosyltransferases and P-glycoprotein. Rifampicin has been shown to enhance CYP2C-mediated metabolism, affect compounds that are transported by P-glycoprotein and metabolized by CYP3A4, and has been used in tuberculosis studies.

Suppliers

XD BIOCHEMS Ltd

XB150450

Krada CPS Industry S.L

KCIS2201100

Nantong Xindao Biotech Ltd

NXB2601040

Chemlyte Solutions

CS180540

Ambeed, Inc.

A146981

Aozeal Certified Standards (AOCS), Inc.

R0012.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Shandong Minglang Chemical Co., Ltd

SMC3501400

Indofine Chemical Co, Inc.

Bio-346

INDAM Inc.

I100200

B.M.P. Bulk Medicines & Pharmaceuticals GmbH

BBMP4402200

AXO Industry SA

AIS150600

X´ian Taicheng Chem Co., Ltd

XTC2901160

Hangzhou Verychem Science & Technology Co., Ltd.

HVST4802400

Xiamen Equation Chemical Co.,Ltd

XECC3201600

Aecochem Corp.

AC140420

CSNpharm, Inc.

CSN16146

Hangzhou Keying Chem Co., Ltd.

HKC3001200

Sigma-Aldrich International GmbH

SI320960

scienTEST - bioKEMIX GmbH

S-B2501000

Finetech Industry Limited

FIL2501000

Xingrui Industry Co., Limited

XIL2901160

Capot Chemical Co., Ltd.

35984

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

200910

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CAS equal suppliers

Rifampin

Hainan Zhongxin Chemical Co., Ltd.

HZC2721088

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CM Fine Chemicals

CFC136544

Rifampin

Gihi Chemicals Co., Limited

GCL216864

Rifampin (0.5/0.7)

Jiwan Pharmaceutical Technology Co., Ltd.

JPT7382952

Rifampin, gamma irradiated

Santa Cruz Biotechnology, Inc.

296271

Prices & Availability

Data is processed

Properties for Rifampicin

Molecular Weight:

822.94 g·mol−1

Density:

~1.35 g/cm³ (Predicted)

Melting point:

183°C (dec.)

Boiling point:

~937.4° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (pH 4.3) (1.3 mg/ml), chloroform, ethyl acetate, methanol (25 mg/ml), DMSO (25 mg/ml), dimethyl sulfoxide, tetrahydrofuran, and water (pH 7.3) (2.5 mg/ml) at 25° C.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R36/38 - Irritating to eyes and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S37/39 - Wear suitable gloves and eye/face protection

Hazard Symbols:

Xn, Xi

Storage temperature :

2-8°C

Alternative Distributors of [Rifampicin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified