Resiniferatoxin | CAS 57444-62-9

Element: resiniferatoxin

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C-S » Chemicals » resiniferatoxin-PX72009

Identification

Resiniferatoxin

CAS:

57444-62-9

EINECS:

Molecular Formula:

C₃₇H₄₀ O₉

MDL:

MFCD00135927

SMILES:

C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)CC6=CC(=C(C=C6)O)OC)O)C)O[C@](O3)(O2)CC7=CC=CC=C7)C(=C)C

Synonym:

resiniferatoxin,euphorbia poisonii ; benzeneaceticacid, 4-hydroxy-3-methoxy-,[3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7h-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methylester, [2s-(2a,3ab,3bb,6ab,9aa,9ba,10a,11ab)]- ; resiniferatoxin,euphorbiapoisonii,highpurity ; resiniferatoxin >99% ; resiniferatoxin from euphorbia poisonii ; benzeneacetic acid,4-hydroxy-3-methoxy-,[(2s,3ar,3bs,6ar,9ar,9br,10r,11ar)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7h-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methylester ; 6-o,7-seco-5,6-dideoxy-6,7-didehydro-20-o-[(4-hydroxy-3-methoxyphenyl)acetyl]-21-dephenyl-21-benzyldaphnetoxin ; daphnetoxin,6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-,20-(4-hydroxy-3-methoxybenzeneacetate) ; resiniferatoxin, 99%, high purity ; resiniferatoxin,highpurity ; resiniferatoxin aus euphorbia poisonii ; (+)-resiniferatoxin ; rtx ; resiniferatoxin

Description

Resiniferatoxin is a potent analog of capsaicin that is an agonist at vanilloid receptorsis. Resiniferatoxin is also an irritant diterpenoid experimentally shown to release substance P from afferent nociceptive specific neurons. Since the compound has a 4-hydroxy-3-methoxyphenyl substituent, Resiniferatoxin has also been shown to produce 3-4 orders of magnitude greater side effects similar to that of capsaicin in the areas of thermoregulation, neurogenic inflammation, as well as agonising VR (vanilloid receptors) (Ki = 43 pM). Resiniferatoxin has also been observed to stimulate PKC (protein kinase C). Resiniferatoxin is an activator of VR1.

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Indofine Chemical Co, Inc.

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Santa Cruz Biotechnology, Inc.

24015

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Data is processed

Properties for Resiniferatoxin

Molecular Weight:

628.72 g·mol−1

Density:

1.35 g/cm3

Boiling point:

768.7°C at 760 mmHg

Flash point:

240.3°C

Solubility:

Soluble in chloroform, DMSO (100 mM), and ethanol (50 mM). Insoluble in water.

Safety & Transport Information

A poison by intracerebral route. When heated to decomposition it emits acrid smoke and irritating vapors.

Risk Codes:

R25 - Toxic if swallowed
R35 - Causes severe burns

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(a)

Hazard Symbols:

A poison.

Storage temperature :

-20°C

RID/ADR certification :

UN 2928 6.1 / PG 2

Alternative Distributors of [Resiniferatoxin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Fermentek Ltd. | Clearsynth Canada INC.

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Mol File:

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MSDS:

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