rac-Sitagliptin | CAS 823817-56-7

Element: sitagliptin

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C-S » Chemicals » rac-sitagliptin-PX77809

Identification

rac-Sitagliptin

CAS:

823817-56-7

EINECS:

Molecular Formula:

C₁₆H₁₅ F₆ N₅ O

MDL:

SMILES:

NC(CC(=O)N1CCN2C(C1)=NN=C2C(F)(F)F)CC1=C(F)C=C(F)C(F)=C1

Synonym:

1-butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)- ; rac-sitagliptinsee: s491000 ; 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine ; 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine ; 7-[1-oxo-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine ; 3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one ; 1,2,4-triazolo[4,3-a]pyrazine,7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-(9ci) ; rac-sitagliptin ; 3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone ; 3-amino-1- [3- (trifluoromethyl) -5,6,7,8-tetrahydro-1,2,4-triazolo [4,3-a] pyrazin-7-yl] -4- (2,4,5-trifluorophenyl) butan-1

Description

Rac-Sitagliptin is a CD26 (trizolopyrazine dipeptidyl peptidase IV, DPP-4) inhibitor. DPP-4 is an enzyme which breaks down incretins such as GLP-1, GIP, and gastrointestinal hormones. rac-Sitagliptin controls the release of insulin by inhibiting these gastrointestinal hormones via inhibiting CD26 (DPP-4). Alternate studies indicate that rac-Sitagliptin can induce hemolysis. Furthermore, rac-Sitagliptin increases the number of insulin-positive β-cells in islets by reducing apoptosis.

Suppliers

BOC Sciences

BS180540

Amadis Chemical Company Limited

ACCL4652325

Santa Cruz Biotechnology, Inc.

208294

Dayang Chem (Hangzhou) Co.,Ltd.

DC4651860

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CAS equal suppliers

7-[1-Oxo-3-Amino-4-(2,4,5-Trifluorophenyl)Butyl]-3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,2,4-Triazolo[4,3-A]Pyrazine

Leap Chem Co., Ltd

LC2948488452

7-[1-Oxo-3-Amino-4-(2,4,5-Trifluorophenyl)Butyl]-3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,2,4-Triazolo[4,3-A]Pyrazine

Skyrun Industrial Co., Ltd.

SI44226132678

7-[1-Oxo-3-Amino-4-(2,4,5-Trifluorophenyl)Butyl]-3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,2,4-Triazolo[4,3-A]Pyrazine

Finipharma Ltd

F2293245864

7-[1-Oxo-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine

ShangHai Biochempartner Co., Ltd.

BCP12219

7-[1-Oxo-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine

Excenen Pharmatech Co., Ltd.

EN-2407

Prices & Availability

Data is processed

Properties for rac-Sitagliptin

Molecular Weight:

407.316 g·mol−1

Solubility:

Soluble in Dichloromethane, Ethyl Acetate and Methanol

Safety & Transport Information

Storage temperature :

Refrigerator

Alternative Distributors of [rac-Sitagliptin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Clearsynth Canada INC.