Prostaglandin D2 serinol amide

Prostaglandin D₂ serinol amide exhibits cannabinoid (CB) agonist activity at the CB₁ receptor, and is an important endogenous monoglyceride species, which is considered to be the natural ligand for the CB₁ receptor. Can also be sequentially metabolized by COX-2 and specific PG synthases to form PG 2-glyceryl esters. In activated RAW 264.7 cells, PGD₂ 2-glyceryl ester is the primary product of 2-AG metabolism in the COX pathway. PGD₂ serinol amide (PGD₂-SA) is a stable analog of PGD₂ 2-glyceryl ester. Unlike PGD₂ 2-glyceryl ester and other fatty acyl 2-glyceryl esters, PGD₂-SA will not isomerize to the less active primary (1-glyceryl) ester.