Prostaglandin E2-1-glyceryl ester | CAS 37497-47-5

Element: prostaglandin glyceryl ester

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C-S » Chemicals » prostaglandin-glyceryl-ester-PX66732

Identification

Prostaglandin E2-1-glyceryl ester

CAS:

37497-47-5

EINECS:

Molecular Formula:

C₂₃H₃₈O₇

MDL:

SMILES:

CCCCCC(O) /C=C/[C@H] 1C(O) CC(=O) C1C/C=CCCCC(=O) OCC(O) CO

Synonym:

9-oxo-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, 2,3-dihydroxypropyl ester ; prostaglandin e2-1-glyceryl ester

Description

Prostaglandin E2-1-glyceryl ester is the glycero-ester of PGE2, that has been shown to be synthesized by incubation of 2-Arachidonoyl glycerol (2-AG) with COX-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures. 2-AG has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. Little is known about the biological activity of these 1-glyceryl prostaglandin derivatives.