Prostaglandin E1 Alcohol | CAS 21562-57-2

Element: prostaglandin alcohol

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C-S » Chemicals » prostaglandin-alcohol-PX55448

Identification

Prostaglandin E1 Alcohol

CAS:

21562-57-2

EINECS:

Molecular Formula:

C₂₀H₃₆O₄

MDL:

SMILES:

CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCCO)O)O

Synonym:

1-decarboxy-1-hydroxymethyl-pge1 ; prostaglandin e1 alcohol ; prost-13-en-9-one,1,11,15-trihydroxy-,(11r,- 13e,15s)- ; tr4161 ; (13e,15s)-9-oxoprosta-13-ene-1,11α,15-triol ; 1-hydroxy prostaglandin e1 ; pge1 alcohol ; (11α,13e,15s)-1,11,15-trihydroxyprost-13-en-9-one ; 1,11alpha,15s-trihydroxy-prost-13e-en-9-one ; (3r)-3β-hydroxy-4α-[(1e,3s)-3-hydroxy-1-octenyl]-5β-(7-hydroxyheptyl)cyclopentanone

Description

Prostaglandin E₁ Alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle, comparable to PGE₁ at concentrations of 0.01 to 10.0 µg/ml. Studies in mice have also demonstrated the ability of PGE₁ alcohol to bind to recombinant EP₃ and EP₄ receptors (K_i = 330 and 190 nM, respectively). Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.