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PRIMA-1

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Formula: C9H15 N O3
CAS: 5608-24-2
search Element: prima
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Identification

Structural Formula
PRIMA-1
CAS:
5608-24-2
EINECS:
Molecular Formula:
C9H15 N O3
MDL:
MFCD04974196
SMILES:
C1CN2CCC1C(=O)C2(CO)CO
Synonym:
prima-1 ; 1-azabicyclo[2.2.2]octan-3-one,2,2-bis(hydroxymethyl)- ; 2,2-dimethylolquinuclidin-3-one ; 7,7-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-8-one ; prima 1 ; nsc 281668 ; 2,2-bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one ; p53 reactivation and induction of massive apoptosis ; 3-quinuclidinone,2,2-bis(hydroxymethyl)- (7ci,8ci) ; 2,2-bis(hydroxymethyl)-3-quinuclidinone


Description

PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is a small molecule identified for its p53 reactivating effect. PRIMA-1 has been shown to restore transcriptional activity and native function to mutant-type p53 systems, which has been directly correlated to reintroduction of p53-dependent apoptosis and destruction of tumor viability.


Suppliers

Ambeed, Inc.
A755385
+
CSNpharm, Inc.
CSN11769
Santa Cruz Biotechnology, Inc.
200927
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CAS equal suppliers

2,2-bis-(Hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Dayang Chem (Hangzhou) Co.,Ltd.
DC1004440176

Prices & Availability




Data is processed


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Properties for PRIMA-1

Molecular Weight:
185.22 g·mol−1
Density:
1.32 g/cm3
Boiling point:
353.7°C at 760 mmHg
Flash point:
167.7°C
Solubility:
Soluble in water (20 mg/ml), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS(PH 7.2) (~2.5 mg/ml).
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R43 - May cause sensitisation by skin contact
Safety Codes:
S36/37 - Wear suitable protective clothing and gloves
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
Store at +4 °C
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Alternative Distributors of [PRIMA-1]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences

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Downloads

Mol File:
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MSDS:
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