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Pimaricin, Streptomyces chattanoogensis

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Formula: C33H47NO13
CAS: 7681-93-8
search Element: chattanoogensis streptomyces pimaricin
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Identification

Structural Formula
Pimaricin, Streptomyces chattanoogensis
CAS:
7681-93-8
EINECS:
231-683-5
Molecular Formula:
C33H47NO13
MDL:
MFCD00135085
SMILES:
C[C@@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@H]3O[C@@H]3C=CC(=O)O[C@H](C)CC=CC=CC=CC=C2)C(O)C(N)[C@@H]1O
Synonym:
natacyn ; delvopos ; delvolan ; mycophyt ; myprozine ; synogil ; pimafucin ; delvocid ; pimaricin ; cl12,625


Description

Pimaricin, Streptomyces chattanoogensis is an antifungal macrolide polyene that binds to cell membrane sterols. Investigations show that the compound predominantly binds to the main sterol in fungal and yeast membranes, ergosterol. Ergosterol is a building block of yeasts and molds, which is responsible for intracellular nutrient transport, and therefore vital for their survival. As ergosterol is not present in the outer membranes of bacteria, these remain unaffected.
Pimarcin has been used as a fungicide in agar media and CYP (cytochrome P450) PimD research proposes that the epoxidiation of Pimaricin occurs through a hydroperoxoferric compound. Pimarcin studies reveal that the regulator PimM binds to eight promoters of Pimarcin genes and its biosynthesis is influenced by a cholesterol oxidase protein encoded by PimE.


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Santa Cruz Biotechnology, Inc.
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Properties for Pimaricin, Streptomyces chattanoogensis

Molecular Weight:
665.73 g·mol−1
Density:
1.0 g/mL at 20 °C(lit.)
Melting point:
2000C (dec)
Boiling point:
952.17° C at 760 mmHg (Predicted)
Solubility:
Soluble in Acetic acid (5 mg/ml), 0.1%HCOOH in Methanol (1 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), DMSO (7 mg/ml), and methanol (~1 mg/ml).
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
Safety Codes:
S24/25 - Avoid contact with skin and eyes
S36 - Wear suitable protective clothing
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [Pimaricin, Streptomyces chattanoogensis]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Haihang Industry Co., Ltd.

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