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Picotamide

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Formula: C21H20N4O3
CAS: 32828-81-2
search Element: picotamide
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Identification

Structural Formula
Picotamide
CAS:
32828-81-2
EINECS:
251-245-7
Molecular Formula:
C21H20N4O3
MDL:
MFCD00866792
SMILES:
COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3
Synonym:
picotamide ; g137 ; n,n'-bis(3-pyridinylmethyl)-4-me ; isophthalamide, 4-methoxy-n,n'-bis(3-pyridylmethyl)- ; n,n'-bis(3-picolyl)-4-methoxyisophthalamide ; 4-methoxy-n,n'-bis(3-pyridylmethyl)isophthaldiamide ; 4-methoxy-n,n'-bis(3-pyridylmethyl)isophthalamide ; 4-methoxy-n,n'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide ; n,n'-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide ; 4-methoxy-n,n'-bis(3-pyridylmethyl)-isophthalamid


Description

Picotamide is a dually active TXA2R (thromboxane A2) and TXA synthase (thromboxane A2 synthase) inhibitor. It has been shown to exhibit platelet inhibitory effects ex vivo and in vitro. It suppresses arachidonic acid, low-dose collagen, and TXA2-induced human platelet aggregation. However, it does not afftect A23187 induced aggregation or primary aggregation by ADP. It has been shown to inhibit the synthesis of TXA2 by platelets in a dose dependent fashion. It has been reported to enhance PGE2 formation, and enhance PGI2 formation by aspirinated endothelial cells. It has also been shown to raise intraplatelet cAMP levels in platelets stimulated with arachidonic acid.


Suppliers

Hefei Hirisun Pharmatech Co., Ltd
HR011239
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Leap Chem Co., Ltd
LC180540
+
Santa Cruz Biotechnology, Inc.
201334
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Prices & Availability




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Properties for Picotamide

Molecular Weight:
376.41 g·mol−1
Density:
~1.2 g/cm3 (Predicted)
Melting point:
128-131° C
Boiling point:
~688.05° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml). Insoluble in water.
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Alternative Distributors of [Picotamide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd.

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