1,2-dioleyoyl-sn-glycero-3-phosphate na ; dopa monosodium salt ; 9-octadecenoic acid (z)-, 1-[(phosphonooxy)methyl]-1,2-ethanediylester, monosodium salt, (r)- ; l-a-phosphatidic acid dioleoyl sodium ; 1,2-dioleoyl-sn-glycero-3-phosphoric acid monosodium salt ; oopa ; l-α-phosphatidic acid, dioleoyl sodium salt ; phosphatidic acid, dioleoyl, sodium salt ; 9-octadecenoic acid(9z)-, 1,1'-[(1r)-1-[(phosphonooxy)methyl]-1,2-ethanediyl] ester, sodium salt(1:1) ; phosphatidic acid, dioleoyl ; 3-sn-phosphatidic acid, 1,2-dioleoyl monosodium salt ; l-alpha-phosphatidic acid, dioleoyl sodium salt ; l-β,γ-dioleoyl-α-phosphatidic acid monosodium salt ; 9-octadecenoicacid (9z)-, 1-[(phosphonooxy)methyl]-1,2-ethanediyl ester, monosodium salt,(1r)- (9ci)
Description
Phosphatidic Acid, Dioleoyl has been shown to activate PKC α, ε, or ζ isotypes in the cytosol of COS cells. This compound not only stimulates PKC-ζ-mediated phosphorylation of distinctive substrates, but additionally causes an upward shift in electrophoretic mobility of PKC &zeta. Furthermore, experiments have reported Phosphatidic Acid to be generated by hydrolysis of phosphatidylcholine, via phospholipase D (PLD). Mechanistic studies suggest activation of PLD by insulin and consequential generation of Phosphatidic Acid which then induces Raf-1 translocation to cell membranes. Raf-1 is an essential component to the mitogen-activated protein kinase cascade, and once it has crossed over to the plasma membrane, other factors may activate it through phosphorylation.
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