Phenylarsine oxide

Phenylarsine Oxide (PAO) is a membrane-permeable protein-tyrosine phosphatase (PTPase) inhibitor with no effect on tyrosine kinase. It inhibits the internalization of cell surface receptors. Phenylarsine Oxide (PAO) is very useful in the study of tyrosine phosphorylation events and the mechanisms that inhibit or block tyrosine phosphorylation. One report applied PAO and TNF to human myeloid cells (ML-1a) to study TNF-dependent NFκB activation. Phenylarsine Oxide (PAO) has been reported to stimulate 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates Lck (lymphocyte-specific protein tyrosine kinase). Since PAO is also an inhibitor of caspases and nuclear apoptotic events, it is useful for the study of apoptosis.