17-phenyl trinor PGF2α isopropyl ester

17-phenyl trinor PGF2α isopropyl ester is the isopropyl ester of the free acid prostaglandin which corresponds to bimatoprost. This free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The bimatoprost isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost.5 At the dose of 3 mg/eye in the monkey, bimatoprost isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.