16-phenyl tetranor Prostaglandin E2

16-phenyl tetranor PGE2 is a metabolically stable tissue selective synthetic analog of PGE2, believed to be five times more potent than PGE2 in causing hypotension in dogs (0.1 μg/kg dose), and comparable to PGE2 in inhibiting histamine-induced bronchoconstriction in conscious guinea pigs. The increased stability toward metabolism can help to explain the increased potency due to a longer half-life in physiological conditions.