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Penitrem A

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Formula: C37H44 Cl N O6
CAS: 12627-35-9
search Element: penitrem
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Identification

Structural Formula
Penitrem A
CAS:
12627-35-9
EINECS:
Molecular Formula:
C37H44 Cl N O6
MDL:
MFCD00083465
SMILES:
CC(=C)C1C(C2C3(O2)C(O1)CCC4(C3(CCC5C4(C6=C7C5OC(C8CC9C8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O
Synonym:
penitrem a, penicillium paxilli ; penitrem a ; penitrem a from penicillium paxilli ; tremortin a ; [2r-(2a,3a,3aa,4as*,4bb,6aa,7a,7db,8b,9ab,14bb,14ca,16ab)]-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2h,6h-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5h,7h)-triol ; 7,8-(epoxymethano)-2h,6h-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5h,7h)-triol,12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-,(2r,3s,3ar,4as,4bs,6ar,7s,7dr,8r,9ar,14bs,14cr,16as)- ; penitrem a nsc354845 ; penitrem a from penicillium palitans ; nsc 354845


Description

Penitrem A, a potent neurotoxin produced by several species in the genus Penicillium, displays a capacity to have numerous effects on ion channels and neurotransmitter release. This compound has also been reported to inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. Additionally, Penitrem A shows the ability to induce an increase in the voltage and frequency of electrical activity recorded from the cerebral cortex. Penitrem A is an inhibitor of MaxiKα.


Suppliers

Iris Biotech GmbH
LS-1052
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Santa Cruz Biotechnology, Inc.
200997
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CAS equal suppliers

penitrem a from penicillium paxilli
Indofine Chemical Co, Inc.
Bio-939

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Properties for Penitrem A

Molecular Weight:
634.27 g·mol−1
Density:
1.44 g/cm3
Melting point:
225-230° C
Solubility:
Soluble in methanol (10 mg/ml), acetone, and DMSO.
Transport Information:
UN 2811 6
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Safety & Transport Information

Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Risk Codes:
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed
Safety Codes:
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(a)
Hazard Symbols:
T+, T
Hazard symbol T Hazard symbol T+
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 2
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Alternative Distributors of [Penitrem A]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | Fermentek Ltd. | Clearsynth Canada INC.

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MSDS:
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