PDDHV is a resiniferatoxin (RTX)-type phorboid vanilloid with capsaicin-like selectivity for VR1, shown to evoke Ca2+ uptake in rat dorsal root ganglion neurons with an EC50 = 70nM, while inhibiting RTX binding to said neurons with a much lower potency (Ki > 10,000 nM). The ability of PDDHV to elicit Ca2+ uptake at sub-micromolar concentrations, while having a much lower binding affinity to rat dorsal root ganglion membranes, represents more than 100 times capsaicin-like pharmacology. PDDHV provides a tool to explore this capsaicin-like, vanilloid pharmacology.
Soluble in DMSO, ethanol, methanol, and chloroform. Insoluble in water.
Transport Information:
UN 2811 6.1/PG 2
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Safety & Transport Information
Risk Codes:
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S27 - Take off immediately all contaminated clothing S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T+
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Alternative Distributors of [PDDHV]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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