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Paxilline

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Formula: C27H33NO4
CAS: 57186-25-1
search Element: paxilline
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Identification

Structural Formula
Paxilline
CAS:
57186-25-1
EINECS:
Molecular Formula:
C27H33NO4
MDL:
MFCD00083464
SMILES:
CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O
Synonym:
14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-( ; paxilline solution ; paxilline from penicillium paxilli ; (2r)-5,6,6a?,7,12,12b,12c,13,14,14a?-decahydro-4b?-hydroxy-2-(1-hydroxy-1-methylethyl)-12b?,12c?-dimethyl-2h-1-benzopyrano[5',6':6,7]indeno[1,2-b]indol-3(4bh)-one ; paxilline, penicillium paxilli ; paxiline ; paxicillin ; 4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-2-alph ; 2h-1-benzopyrano(5?,6?:6,7)indeno(1,2-b)indol-3(4bh)-one,5,6,6a,7,12,12b,12c,1 ; paxilline


Description

Paxilline is an indole alkaloid isolated from Penicillium paxilli. Paxilline has been shown to selectively and reversibly block the high conductance Ca2+-activated K+ channel. In neutrophils, Paxilline blockage of Maxi-K channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. When paxilline was applied to the smooth muscle of the rat vas deferens at more positive potentials than -40 mV up to 15 mV, significant depolarization of the smooth muscle contractions was observed. Paxilline is an inhibitor of MaxiKα, IP3R and SERCA.


Suppliers

Iris Biotech GmbH
LS-1050
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Leap Chem Co., Ltd
LC162486
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Santa Cruz Biotechnology, Inc.
3588
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CAS equal suppliers

Paxilline, 97+%
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Paxilline, Penicillium paxilli
A.G. Scientific
AS13504050
paxilline from penicillium paxilli
Indofine Chemical Co, Inc.
Bio-937

Prices & Availability




Data is processed


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Properties for Paxilline

Molecular Weight:
435.56 g·mol−1
Density:
1.31 g/cm3 (Predicted)
Melting point:
252° C
Boiling point:
648.8° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (50 mg/ml), acetone (5 mg/ml), and chloroform (10 mg/ml).
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Safety & Transport Information

Risk Codes:
R11 - Highly flammable
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36 - Irritating to eyes
R36/37/38 - Irritating to eyes, respiratory system and skin
R41 - Risk of serious damage to eyes
Safety Codes:
S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(b)
Hazard Symbols:
T, Xn, F
Hazard symbol T Hazard symbol F Hazard symbol Xn
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 3
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Alternative Distributors of [Paxilline]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Fermentek Ltd.

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Downloads

Mol File:
-/-
MSDS:
-/-




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